Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
162
6.9
Adenovirus
499
21.2
Adenovirus + Modified vaccinia Ankara virus (MVA)
11
0.5
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.3
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.3
Bifidobacterium longum
1
0
E. coli
2
0.1
Flavivirus
8
0.3
Gene gun
5
0.2
Herpes simplex virus
86
3.7
Lactococcus lactis
6
0.3
Lentivirus
135
5.7
Lipofection
115
4.9
Listeria monocytogenes
21
0.9
Measles virus
10
0.4
Modified Vaccinia Ankara virus (MVA)
7
0.3
mRNA Electroporation
5
0.2
Naked/Plasmid DNA
409
17.4
Naked/Plasmid DNA + Adenovirus
4
0.2
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + RNA transfer
1
0
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
3
0.1
Newcastle disease virus
1
0
Non-viral
2
0.1
Poliovirus
2
0.1
Poxvirus
68
2.9
Poxvirus + Vaccinia virus
35
1.5
Retrovirus
441
18.7
RNA transfer
43
1.8
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.4
Salmonella typhimurium
4
0.2
Semliki forest virus
2
0.1
Sendai virus
4
0.2
Shigella dysenteriae
1
0
Simian Immunodeficiency Virus (SIVagm)
1
0
Simian virus 40
1
0
siRNA
5
0.2
Sleeping Beauty transposon
10
0.4
Streptococcus mutans
1
0
Vaccinia virus
124
5.3
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
3
0.1
Vibrio cholerae
1
0
Unknown
76
3.2
Total
2356