Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
127
5.9
Adenovirus
471
22
Adenovirus + Modified vaccinia Ankara virus (MVA)
10
0.5
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.4
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.3
Bifidobacterium longum
1
0
E. coli
2
0.1
Flavivirus
8
0.4
Gene gun
5
0.2
Herpes simplex virus
68
3.2
Lactococcus lactis
6
0.3
Lentivirus
101
4.7
Lipofection
115
5.4
Listeria monocytogenes
11
0.5
Measles virus
9
0.4
Minimalistic, immunologically defined gene expression (MIDGE)
1
0
Modified Vaccinia Ankara virus (MVA)
7
0.3
mRNA Electroporation
4
0.2
Naked/Plasmid DNA
376
17.6
Naked/Plasmid DNA + Adenovirus
3
0.1
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
2
0.1
Newcastle disease virus
1
0
Poliovirus
1
0
Poxvirus
68
3.2
Poxvirus + Vaccinia virus
32
1.5
Retrovirus
412
19.2
RNA transfer
39
1.8
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.4
Salmonella typhimurium
4
0.2
Semliki forest virus
2
0.1
Sendai virus
3
0.1
Shigella dysenteriae
1
0
Simian Immunodeficiency Virus (SIVagm)
1
0
Simian virus 40
1
0
siRNA
3
0.1
Sleeping Beauty transposon
9
0.4
Streptococcus mutans
1
0
Vaccinia virus
119
5.6
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
3
0.1
Vibrio cholerae
1
0
Unknown
73
3.4
Total
2142