Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
227
8.1
Adenovirus
535
19.1
Adenovirus + Modified vaccinia Ankara virus (MVA)
11
0.4
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.3
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.2
Bifidobacterium longum
1
0
CRISPR-Cas9
10
0.4
E. coli
2
0.1
Flavivirus
8
0.3
Gene gun
5
0.2
Herpes simplex virus
95
3.4
Human Rhinovirus (RG-HRV16)
1
0
Lactococcus lactis
6
0.2
Lentivirus
236
8.4
Lipofection
119
4.2
Listeria monocytogenes
31
1.1
Measles virus
14
0.5
Modified Vaccinia Ankara virus (MVA)
9
0.3
mRNA Electroporation
6
0.2
Naked/Plasmid DNA
446
15.9
Naked/Plasmid DNA + Adenovirus
3
0.1
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + RNA transfer
1
0
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
3
0.1
Newcastle disease virus
1
0
Non-viral
1
0
PiggyBacTM (PB) Transposon
1
0
Poliovirus
5
0.2
Poxvirus
70
2.5
Poxvirus + Vaccinia virus
39
1.4
Retrovirus
496
17.7
Retrovirus + Lentivirus
1
0
RNA transfer
51
1.8
RNA transfer + Naked/Plasmid DNA
1
0
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.3
Salmonella typhimurium
4
0.1
Semliki forest virus
2
0.1
Sendai virus
4
0.1
Shigella dysenteriae
1
0
Simian virus
2
0.1
siRNA
5
0.2
Sleeping Beauty transposon
11
0.4
Streptococcus mutans
1
0
Vaccinia virus
133
4.7
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
6
0.2
Vibrio cholerae
1
0
Unknown
159
5.7
Total
2805