Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
137
6.2
Adenovirus
480
21.7
Adenovirus + Modified vaccinia Ankara virus (MVA)
11
0.5
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.4
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.3
Bifidobacterium longum
1
0
E. coli
2
0.1
Flavivirus
8
0.4
Gene gun
5
0.2
Herpes simplex virus
73
3.3
Lactococcus lactis
6
0.3
Lentivirus
114
5.2
Lipofection
115
5.2
Listeria monocytogenes
15
0.7
Measles virus
9
0.4
Modified Vaccinia Ankara virus (MVA)
7
0.3
mRNA Electroporation
4
0.2
Naked/Plasmid DNA
387
17.5
Naked/Plasmid DNA + Adenovirus
3
0.1
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
2
0.1
Newcastle disease virus
1
0
Non-viral
1
0
Poliovirus
1
0
Poxvirus
68
3.1
Poxvirus + Vaccinia virus
33
1.5
Retrovirus
417
18.9
RNA transfer
39
1.8
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.4
Salmonella typhimurium
4
0.2
Semliki forest virus
2
0.1
Sendai virus
4
0.2
Shigella dysenteriae
1
0
Simian Immunodeficiency Virus (SIVagm)
1
0
Simian virus 40
1
0
siRNA
5
0.2
Sleeping Beauty transposon
10
0.5
Streptococcus mutans
1
0
Vaccinia virus
121
5.5
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
3
0.1
Vibrio cholerae
1
0
Unknown
76
3.4
Total
2210