Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
109
5.5
Adenovirus
458
22.9
Adenovirus + Modified vaccinia Ankara virus (MVA)
6
0.3
Adenovirus + Retrovirus
3
0.2
Adenovirus + Sendai virus
1
0.1
Adenovirus + Vaccinia virus
7
0.4
Alphavirus (VEE) Replicon Vaccine
1
0.1
Antisense oligonucleotide
6
0.3
Bifidobacterium longum
1
0.1
E. coli
2
0.1
Flavivirus
8
0.4
Gene gun
5
0.3
Genomic DNA (no vector)
1
0.1
Herpes simplex virus
62
3.1
Lactococcus lactis
5
0.3
Lentivirus
71
3.6
Lipofection
113
5.7
Listeria monocytogenes
9
0.5
Measles virus
6
0.3
Modified Vaccinia Ankara virus (MVA)
7
0.4
mRNA Electroporation
2
0.1
Naked/Plasmid DNA
355
17.8
Naked/Plasmid DNA + Adenovirus
3
0.2
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + Vaccinia virus
3
0.2
Naked/Plasmid DNA + Vesicular stomatitis virus
2
0.1
Newcastle disease virus
1
0.1
Poliovirus
1
0.1
Poxvirus
67
3.4
Poxvirus + Vaccinia virus
30
1.5
Retrovirus
389
19.5
RNA transfer
33
1.7
RNA virus
5
0.3
Saccharomyces cerevisiae
8
0.4
Salmonella typhimurium
3
0.2
Semliki forest virus
2
0.1
Sendai virus
2
0.1
Shigella dysenteriae
1
0.1
Simian Immunodeficiency Virus (SIVagm)
1
0.1
Simian virus 40
1
0.1
siRNA
2
0.1
Sleeping Beauty transposon
8
0.4
Stem Cell Transplantation
1
0.1
Streptococcus mutans
1
0.1
Vaccinia virus
119
6
Venezuelan equine encephalitis virus replicon
3
0.2
Vesicular stomatitis virus
3
0.2
Vibrio cholerae
1
0.1
Unknown
66
3.3
Total
1996