Vector
Gene Therapy Clinical Trials
Number
%
Adeno-associated virus
183
7.4
Adenovirus
509
20.7
Adenovirus + Modified vaccinia Ankara virus (MVA)
11
0.4
Adenovirus + Retrovirus
3
0.1
Adenovirus + Sendai virus
1
0
Adenovirus + Vaccinia virus
8
0.3
Alphavirus (VEE) Replicon Vaccine
1
0
Antisense oligonucleotide
6
0.2
Bifidobacterium longum
1
0
CRISPR-Cas9
7
0.3
E. coli
2
0.1
Flavivirus
8
0.3
Gene gun
5
0.2
Herpes simplex virus
90
3.7
Lactococcus lactis
6
0.2
Lentivirus
158
6.4
Lipofection
116
4.7
Listeria monocytogenes
25
1
Measles virus
10
0.4
Modified Vaccinia Ankara virus (MVA)
8
0.3
mRNA Electroporation
5
0.2
Naked/Plasmid DNA
419
17
Naked/Plasmid DNA + Adenovirus
3
0.1
Naked/Plasmid DNA + Modified Vaccinia Ankara virus (MVA)
2
0.1
Naked/Plasmid DNA + Vaccinia virus
3
0.1
Naked/Plasmid DNA + Vesicular stomatitis virus
3
0.1
Newcastle disease virus
1
0
Non-viral
1
0
Poliovirus
3
0.1
Poxvirus
70
2.8
Poxvirus + Vaccinia virus
36
1.5
Retrovirus
459
18.6
RNA transfer
48
1.9
RNA transfer + Naked/Plasmid DNA
1
0
RNA virus
5
0.2
Saccharomyces cerevisiae
9
0.4
Salmonella typhimurium
4
0.2
Semliki forest virus
2
0.1
Sendai virus
4
0.2
Shigella dysenteriae
1
0
Simian virus
2
0.1
siRNA
5
0.2
Sleeping Beauty transposon
10
0.4
Streptococcus mutans
1
0
Vaccinia virus
125
5.1
Venezuelan equine encephalitis virus replicon
3
0.1
Vesicular stomatitis virus
3
0.1
Vibrio cholerae
1
0
Unknown
76
3.1
Total
2463